Along with its needed effects, ibandronate (the active ingredient contained in Boniva) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. The list of Prolia side effects below have been reported on the website RxList. It’s a long one and, according to the website, it’s doesn’t include all of them. It’s a long one and, according to the website, it’s doesn’t include all of them. Summary. Liver disorder is found among people who take Boniva, especially for people who are female, 60+ old , have been taking the drug for 1 - 2 years, also take medication Fosamax, and have Asthma. Common side effects of boniva include confusion, disorientation, irregularity, vomiting, muscle cramps, seizures, convulsions, heartburn, tingling and delusional. BONIVA is available as a white, oblong, 150 mg film-coated tablet for once-monthly oral administration. One 150 mg film-coated tablet contains 168.75 mg ibandronate monosodium monohydrate, equivalent to 150 mg free acid. I read the drug insert several days ago. The side effects were minimal but I don't remember specifically about the liver. ( don't believe so) The oncologist still wants her to take an oral calcium & Vit.D supplement. Our Boniva Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Find information about common, infrequent and rare side effects of Boniva Oral. I have had a bout with panceratitis, they have found some kind of mass on the left side that loops in and out of my small bowel that they would rather not touch UNLESS IT GROWS (can you believe that?) plus they have found cysts on my kidneys and liver that they are watching. Inform patients that the most common side effects of Boniva include arthralgia, back pain, hypertension, and abdominal pain. Flu-like symptoms (acute phase reaction) may occur within 3 days following infusion, and usually subside within 24-48 hours without specific therapy.