I have taken oxycodone before around noon for back pains, 5mg. and then advil pm at night around 9 30 - 10 and everything was okay. told me before I could mix tylenol with advil and it would equal a pain pill without the narcotic effect. I don't remember how many of each to take and how many hours apart to take each of them. Oxycodone is an opioid pain medication, sometimes called a narcotic. Ibuprofen is a nonsteroidal anti inflammatory drug (NSAID). ibuprofen and oxycodone works by reducing substances in the body that cause pain, fever, and inflammation. I have Darvocet, Lortab 7,5, Percocet 10, and Mepergan Fortis and Tylenol PM. I have been told I can take all of these. I also have Bextra which is a new anti-imflamatory. Advil PM is ibuprofen and dyphenhydramine (Benadryl). They are safe to take together. Advil is a pain reliever and fever reducer, of course, and the dyphenhydramine is actually an antihistamine. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Le on is it okay to take advil and percocet together: This combination may be very effective on a short-term basis, such as treating pain due to surgery or fracture. Advil PM, if the directions say that it is okay to take one or two at a time, then it should be okay. As for oxycodone, you need to follow your Drs instructions and take only the prescribed amount. As for oxycodone, you need to follow your Drs instructions and take only the prescribed amount. can you take percocet with tylenol pm, It solves Effects – – Percocet / Tylenol 3 Question Drugs-ForumIf Drugs-Forum is useful to you, take one minute to keep it online another Effects – Percocet / Tylenol 3 Question Mixing opiates can be can you mix tylenol pm and percocet OnlineDrug Best Buy can you mix tylenol pm and percocet. If after taking Percocet your pain is not relieved, (unless you've been on your dose for a long time and developed a tolerance, and therefore it's not working, your pain has to be really severe. A doctor who knows your history will make the best decision on your future treatment.