The simple answer to the question 'can Zoloft cause permanent tinnitus' is yes, and that goes for for all the SSRI's. According to Dr Stuart Shipko, who runs a panic disorder clinic in CA, Zoloft is the worst of the lot though. Ringing in the ears (tinnitus) can be caused by a number of medications, including some antidepressants. Not all antidepressants cause tinnitus. If your antidepressant is the cause of your tinnitus, switching to another medication may solve the problem, but don't quit taking your medication without medical guidance. To receive news and publication updates for Case Reports in Psychiatry, enter your email address in the box below. Ototoxicity may be reversible or may be permanent, depending on the type of medication used, dosage and duration of treatment. There are many other medications that have been listed as potentially ototoxic. The simple answer to the question 'can Zoloft cause permanent tinnitus' is yes, and that goes for for all the SSRI's. According to Dr Stuart Shipko, who runs a panic disorder clinic in CA, Zoloft is the worst of the lot though. Viral infection: If you had some sort of viral infection, it can cause temporary tinnitus and/or permanent changes in hearing. In most cases, viruses may temporarily change our ability to perceive sounds, but as our body fights off the virus, the ringing subsides. Hi all! Noticed my tinnitus 1 week ago. I've changed my OCD meds from clomipramine to sertraline (zoloft) some days ago. Now, after checking for a noise in my PC, I noticed that in a silent ambient, I have a constant high pitch noise in my head. Okay, so I am a 15 year old male. I've had tinnitus my whole life, but it was always at a pretty low volume and never bothered me that much. Most of the time I forgot I had it. I would also want to know about anyone whose tinnitus side effect did not go away, and whether they stayed on zoloft anyway with the accompanying tinnitus, or stopped taking zoloft. I m hoping that nobody has experienced permanent tinnitus as a result of zoloft, but I guess I should know about that, too.