Premarin (conjugated estrogens) Vaginal Cream should not be used if you have unusual vaginal bleeding, have or had cancer, had a stroke or heart attack, have or had blood clots or liver problems, have a bleeding disorder, are allergic to any of its ingredients, or think you may be pregnant. Do not use PREMARIN Vaginal Cream for conditions for which it was not prescribed. Do not give PREMARIN Vaginal Cream to other people, even if they have the same symptoms you have. It may harm them. Do not give PREMARIN Vaginal Cream to other people, even if they have the same symptoms you have. How to use Premarin Cream With Applicator. Read the Patient Information Leaflet if available from your pharmacist before you start using this medication and each time you get a refill. Instructions for use of Estrogen vaginal cream What is Estrogen vaginal cream? Estrogen is a female hormone which controls many processes in the female body. During menopause, estrogen production slows down and then stops. Estrogen vaginal cream is supplied as a brand name of either Estrace or Premarin. What is Estrogen cream used for? Estrogen vaginal cream is used to decrease menopause. The cream should be used on a regular cycle, with 3 weeks of use followed by 1 week off. To use the applicator, remove the cap of the tube of cream and screw the nozzle end of the applicator onto the tube. Premarin, the major brand of CEEs in use, is manufactured by Wyeth and was first marketed in 1941 in Canada and in 1942 in the United States. It is the most commonly used form of estrogen in menopausal hormone therapy in the United States. Premarin Vaginal Cream (conjugated estrogens) is a mixture of estrogen hormones, a female sex hormone produced by the ovaries, used to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse. Premarin Vaginal Cream is clinically proven to relieve moderate to severe painful intercourse caused by menopausal changes. Unlike over-the-counter lubricants, Premarin Vaginal Cream delivers estrogens. Do not use Premarin Vaginal Cream if you are pregnant. You should not use Premarin Vaginal Cream if you have: undiagnosed vaginal bleeding , liver disease , a bleeding disorder , if you will be having major surgery , or if you have ever had a heart attack , a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina. You should not use this medicine if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.