If your dog weighs 15 pounds, then you should give him 15mg of Benadryl 3 times a day. If you are going to give Benadryl in liquid form, then the dosage should be 0.4ml for 1lb of the body weight. For a reference, a US teaspoon can hold up to 5ml. Benadryl dosage for dogs - I've heard that you can give benadryl to a dog, so how much should I give to my dog with allergies - weighs around 25 lbs. Benadryl for Dogs: The Do’s & Don’ts, Dosage, Side Effects, And More If your dog or emotional support animal suffers from severe allergies or allergic reactions to things around them, then you know how hard it is to watch them go through that pain. Give 1mg of Benadryl per pound such that if your dog weighs 30 pounds, you should give it 30 mg of Benadryl. Administer the medicine three times in a day How much Benadryl should I give? The standard dosage for oral Benadryl is 1 mg per pound of body weight, given 2-3 times a day. Most drug store diphenhydramine tablets are 25 mg, which is the size used for a 25 pound dog. We just came back from a 10 day vacation, and our dog (6yo female, spayed, white english lab) has approximately 10 small, hard lumps under her skin (neck, hip, underbelly, shoulder). They are very fir … Overdose of Benedryl = Too Much Benedryl. I'm going to assume you are asking about an acute overdose, not long-term use. Although diphenhydramine (Benadryl) is usually considered an antihistamine, it is also a potent anticholinergic agent. Giving Benadryl to your dog: should you do it? Is it helpful and harmless? Or is Benadryl for dogs dangerous and a bad idea? Used properly, in the right situations, Benadryl can be a lifesaver—preventing headaches and alleviating discomfort for your dog. Available over-the-counter, most Benadryl tablets are 25 mg each--but it is important to always check the label ( a children's Benadryl might be best for small dogs). Abiding by the one mg/pound dose, one 25 mg tablet would be the correct dose for a 25-pound dog. The dose can be repeated twice in the day. How much Benadryl can I give my dog and is it safe? So, how much Benadryl can I give my dog? The amount will depend on the weight of your dog. However, the general guidelines require you to give 1mg of Benadryl per pound such that if your dog weighs 30 pounds, you should give it 30 mg of Benadryl. Administer the medicine three times in a day, after every eight hours. However, it is better to.