Find information about common, infrequent and rare side effects of Wellbutrin XL Oral. Wellbutrin (Bupropion) Side Effects Four out of every thousand people taking less than 450 mg daily experience seizures; over 450 mg daily, the risk increases seven fold. Also important to note is that 68% to 77% of bupropion-induced seizures occur within the first 4 hours of taking the drug. Paranoia is found among people who take Wellbutrin xl, especially for people who are female, 30-39 old , have been taking the drug for 6 - 12 months, also take medication Lamictal, and have Bipolar disorder. This study is created by eHealthMe based on reports of 13,811 people who have side effects when taking Wellbutrin xl from FDA, and is updated regularly. In Summary. Commonly reported side effects of bupropion include: insomnia, nausea, pharyngitis, weight loss, constipation, dizziness, headache, and xerostomia. Note: This document contains side effect information about bupropion. Some of the dosage forms listed on this page may not apply to the brand name Wellbutrin. Can Wellbutrin cause Paranoia? Paranoia is a known side effect of Wellbutrin. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. - Page 3 Can Wellbutrin cause Paranoia? Paranoia is a known side effect of Wellbutrin. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Our Wellbutrin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. About this FactMed analysis covering adverse side effect reports of WELLBUTRIN SR patients who developed PARANOIA. FactMed provides MD-approved analysis to help both patients, researchers, and physicians accurately assess the risk profile for more than 20,000 different pharmaceutical products. My odd side effects are jealousy/paranoia/crying spells. I was not a jealous spouse before. The first jealousy rage happened four weeks after starting Wellbutrin 300xl. It has become more frequent and is really stressful for my honey (and crazy-feeling for me!). I really wish these bad side effects weren't happening because the Wellbutrin is so good in other ways.