Ibuprofen is used primarily to treat fever (including post-vaccination fever), mild to moderate pain (including pain relief after surgery), painful menstruation, osteoarthritis, dental pain, headaches, and pain from kidney stones. This medication is typically used twice a day. However, your doctor or pharmacist may have suggested a different schedule that is more appropriate for you. Overview. Rheumatoid arthritis is a long-term, autoimmune disease that causes joint swelling (inflammation), pain, redness, warmth, and stiffness. DESCRIPTION. ARTHROTEC (diclofenac sodium/misoprostol) is a combination product containing diclofenac sodium, a nonsteroidal anti-inflammatory drug (NSAID) with analgesic properties, and misoprostol, a gastrointestinal (GI) mucosal protective prostaglandin E 1 analog. If you’ve used misoprostol alone, you can expect pain in your lower abdominal and back pain for one or two weeks. Sometimes, it could be longer, and misoprostol success rate for an abortion is quite low when used alone compared with combination with mifepristone. Diclofenac interacts with many different drugs. It’s always important to tell your doctor and pharmacist about all of the treatments you are taking. Consider the benefits and risks before neuraxial intervention in patients anticoagulated or to be anticoagulated for thromboprophylaxis. Epidural or spinal hematomas that may result in long-term or permanent paralysis may occur in patients who are anticoagulated and are receiving neuraxial anesthesia or undergoing spinal puncture. Diclofenac-misoprostol oral tablet is available as a brand-name drug and a generic drug. Brand name: Arthrotec. Diclofenac-misoprostol comes only as a delayed-release oral tablet. I have been taking Vimovo for 2 years at $10 copay. Recently it changed, and I have to pay $75 but AstraZeneca gives me a $65 rebate. I do not know why Vimovo works so well, but I recently switched to prescribed naproxen 500mg and OTC esomeprazole, and I went from pain-free to agony within three days. Medical uses. Like other NSAIDs, it is useful in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted in the body to the active NSAID.