What will happen if a patient drinks alcohol while taking naltrexone? Naltrexone does not reduce the effects of alcohol that impair coordination and judgment. Naltrexone may reduce the feeling of intoxication and the desire to drink more, but it will not cause a severe physical response to drinking. You most certainly can get drunk on Naltrexone, but I don't think it is recommended. How most of us drink here is never recommended though. You however physically cannot catch a buzz from opoids. How most of us drink here is never recommended though. As you proceed to drink while taking naltrexone, your brain is no longer being reinforced by endorphins. This produces pharmacological extinction—Sinclair’s amazing discovery—which automatically weakens the wiring causing your addiction. De-addiction happens slowly but surely with I have found that drinking while on Naltrexone had made me extremely ill. Vomiting and headache. Ive only had alcohol twice since taking it, and been very sick both times. I look at it as divine intervention. Drinking Alcohol while Taking Naltrexone There appear to be no significant dangers associated with taking naltrexone and drinking alcohol. Information provided by the FDA and by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) report that individuals who drink alcohol and use naltrexone: You should inform your physician of whatever medication you are currently taking so that possible interactions can be evaluated. Because naltrexone is broken down by the liver, other medications that can affect liver function may affect the dose of naltrexone. Good wine still can taste good so I don't see the difference but I DO feel the drug in my system since I do not take it often (only if I drink) so when I do take it it feels like there is a drug in my system i.e.: sleeplessness and sometimes a fuzzy around the edges feeling. Taking naltrexone will not help you drive more safely or operate machinery after you’ve had a drink. A person who drinks while taking naltrexone may feel sick and suffer from withdrawal symptoms such as: My experience with naltrexone is limited to the clients I work with in a treatment center; therefore, the option of drinking while taking it isn't a likely concern. If I were you, I'd speak to his doctor about what he is doing, as the doctor can better advise you if he should continue to take naltrexone. There may be a negative interaction between Low Dose Naltrexone and alcohol. 525 Reviews about the risks, side effects and symptoms for taking Low Dose Naltrexone while drinking alcohol.