Certain neurotransmitters, such as serotonin and noradrenaline, are linked to mood and emotion. Neurotransmitters may also affect pain signals sent by nerves, which may explain why some antidepressants can help relieve long-term pain. Reduced affect should be distinguished from apathy, which explicitly refers to a lack of emotion, whereas reduced affect is a lack of emotional expression regardless of whether emotion is actually reduced or not. I was on fluoxetine a couple years ago, and got off due to the forgetfulnes and the lump in my throat and upset tummy along with the tired and lack of motivation. I am back on the product due to the loss of the love of my heart. Its been 4 days now and I have had these panics waking me up for a week. I found him in the floor ad rushed him to the hospital. He never came home. Passed at 52 yrs. I think Prozac is starting to make me feel like I'm not myself. I don't know. Yesterday, I was feeling pretty quiet and today, ehh. I just don't know. I don't feel like talking, which isn't what I normally feel like. Grief and depression is normal when experiencing a loss. Here are signs it may be time to talk to a doctor. Along with its needed effects, fluoxetine (the active ingredient contained in Prozac) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. On the contrary, some felt no emotion at all. One person said he was “unable to enjoy” a seemingly happy and good life. They described feeling “numb”, “total nothingness” and a complete loss of interest and motivation in life. One man said “he’d gone off the boil”. One woman described herself; I have been taking prozac for over 5 years and i have no emotion about anything. People die and i don't cry, family gets hurt i dont get upset. Prozac allowed me to be the person I wanted to be. Looking back, I should have seen this as a red flag. It worked really well, almost like Placebo. This handful of existing studies underscores the lack of large-scale clinical studies on the prevalence of SSRI-induced indifference, particularly with regard to emotional blunting (i.e., apathy has been more studied), in either psychiatric or primary care populations, despite the high prescription rates for these types of antidepressants.