Oral ketoconazole. Oral ketoconazole was discontinued in New Zealand 1 December 2013. As it may still be available elsewhere, information about the product is included below. Ketoconazole reaches the surface of the skin through normal blood circulation, sweat and sebum (skin oils). Very high concentrations of the drug develop within the skin, so it is effective in treating superficial fungal. Ketoconazole side effects. Get emergency medical help if you have signs of an allergic reaction (hives, fever, chest pain, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). Call your doctor at once if you have: fast or pounding heartbeats, fluttering in your chest. 48 Likes, 2 Comments - College of Medicine & Science (@mayocliniccollege) on Instagram: “🚨 Our Ph.D. Program within @mayoclinicgradschool is currently accepting applications! As a student,…” Get the latest in-depth ratings, reviews, and buying advice on personal care and health products from Consumer Reports, so you can make the right choice. decided to restart oral ketoconazole, monitor the patient frequently to detect any recurring liver injury from the drug. QT Prolongation and Drug Interactions Leading to QT Prolongation. Ketoconazole can prolong the QT interval. Co-administration of the following drugs with ketoconazole is contraindicated: dofetilide, quinidine, pimozide, and cisapride. Ketoconazole can cause elevated plasma. Ketoconazole can cause serious (possibly fatal) side effects and drug interactions.Therefore, it should only be used when other treatments have not worked, are not available, or cannot be taken by you.