However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Do not double doses. If you miss more than one dose of clonidine tablets, check with your doctor right away. Oral clonidine premedication in children at a dose of 2-4 mcg/kg decreases the dose of intravenous barbiturate required for induction of anaesthesia and also reduces halothane requirement for maintenance of anaesthesia 17,78. Clonidine (Catapres, Catapres-TTS) is an oral and topical (applied to the skin) medication prescribed by a doctor for the treatment of high blood pressure (hypertension). Maintenance Dose. Further increments of 0.1 mg per day may be made at weekly intervals if necessary until the desired response is achieved. Taking the larger portion of the oral daily dose at bedtime may minimize transient adjustment effects of dry mouth and drowsiness. Toxicology: In several studies with oral clonidine hydrochloride, a dose-dependent increase in the incidence and severity of spontaneous retinal degeneration was seen in albino rats treated for six months or longer. Tissue distribution studies in dogs and monkeys showed a concentration of clonidine in the choroid. -Taking the larger portion of the oral daily dose at bedtime may minimize dry mouth and drowsiness and also minimize the risk of morning-associated cardiovascular events (i.e., stroke, transient ischemic attacks, myocardial infarction, sudden cardiac death). Clonidine Dosage The recommended dosage of clonidine for the tablet form of this medication is 0.1 mg twice daily. If you are using the skin patch, your healthcare provider may recommend that you start with the clonidine-1 patch (applied once a week). Safe and effective use of immediate-release oral clonidine and transdermal clonidine have not been established in neonates, infants, children or adolescents. Safety and efficacy of Kapvay extended release tablets have not been established in children 6 years. Because clonidine decreases blood pressure and heart rate, the manufacturer recommends cautious use of clonidine extended-release. Medscape - Hypertension, cancer pain-specific dosing for Catapres, Catapres-TTS (clonidine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Clonidine oral tablet can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully.