DOSAGE AND ADMINISTRATION Dosage In Patients With MDD, OCD, PD, PTSD, And SAD. The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. The Zoloft dosage that doctors usually recommend for adults with depression or obsessive-compulsive disorder is 50 mg once a day. Although the starting dose for people with panic disorder, post-traumatic stress disorder, or social anxiety disorder is typically 25 mg daily, healthcare providers often increase that dose to 50 mg daily. Zoloft belongs to a group of selective serotonin reuptake inhibitors (SSRI) and is designed for oral administration. Zoloft treats depression and other similar medical conditions by altering the chemicals in the brain which cause panic, anxiety and obsessive-compulsive symptoms when getting out of balance. WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS. ZOLOFT and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. Zoloft is a brand name of the active ingredient Sertraline that has been developed by the pharmaceutical company Pfizer. ZOLOFT has helped treat the following conditions in adults: Major Depressive Disorder (MDD), Obsessive-Compulsive Disorder (OCD), Panic Disorder, Posttraumatic Stress Disorder (PTSD), Premenstrual Dysphoric Disorder (PMDD), and Social Anxiety Disorder. Zoloft/sertraline is good for both depression and OCD. Wellbutrin/bupropion is good for major depression. These could well be the combination you need. Find Help. Search the Resource Directory for therapists, clinics, treatment programs, support groups, and organizations (such as affiliates and global partners) specializing in OCD and Related Disorders in your area. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products.