WARNING: SUICIDALITY AND ANTIDEPRESSANT DRUGS. ZOLOFT and other antidepressant medicines may increase suicidal thoughts or actions in some people 24 years of age and younger, especially within the first few months of treatment or when the dose is changed. DOSAGE AND ADMINISTRATION Dosage In Patients With MDD, OCD, PD, PTSD, And SAD. The recommended initial dosage and maximum ZOLOFT dosage in patients with MDD, OCD, PD, PTSD, and SAD are displayed in Table 1 below. The recommended starting dosage for those with premenstrual dysphoric disorder (PMDD) is Zoloft 50 mg once a day, either throughout the entire menstrual cycle or just during the last two weeks of the cycle (before a woman's period starts), depending on your healthcare provider's instructions. I believe a higher dosage can help. I have taken effexor for several years and have worked my way up to two 150s a day. For some reason after taking it a while I would have to increase it. The Zoloft dosage that doctors usually recommend for adults with depression or obsessive-compulsive disorder is 50 mg once a day. Although the starting dose for people with panic disorder, post-traumatic stress disorder, or social anxiety disorder is typically 25 mg daily, healthcare providers often increase that dose to 50 mg daily. Zoloft, or sertraline, is an antidepressant in the selective serotonin reuptake inhibitor, or SSRI, class. Studies show that SSRIs may increase the brain’s levels of melatonin, a neurotransmitter that can promote sleepiness and help correct an irregular sleeping pattern. Zoloft is a brand name of the active ingredient Sertraline that has been developed by the pharmaceutical company Pfizer. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs). What is Zoloft? Zoloft is the brand name for the generic drug sertraline. Zoloft (sertraline) belongs to the class of antidepressant drugs and are conventionally described by their mechanism of action as selective serotonin reuptake inhibitors (SSRIS). I am currently on 100mg of zoloft for my depression and although i do see signs of improvement im not 100%, my dr suggested to increase my dose to 150 and if it didnt work she will refer me to a psychiatrist, im on my 6 weeks on zoloft.