To avoid serious side effects, you probably shouldn’t take ibuprofen and aspirin together. However, if you feel the need to take both, talk to your doctor first. Technically no interaction exists, but it is important to discuss OTC use with your doctor if you have certain conditions. Both Ibuprofen and all NSAIDS (aspirin, naproxen) along with Antihistamines (benadryl) can cause fluid retention. You can definitely take them both together safely, Long said, adding that you should check with your doctor to make sure you do not have an allergy or health condition that would be a problem. Yes, you can use acetaminophen and ibuprofen together. That combination of drugs controls very high fever in children. You need to know that they are not the similar drugs. You can take both together, as they both perform different functions. There should be no side effects, given you have no side effects from either individually. Yes you can take them together. What I do is stagger them, where I take tylenol for one dose then when it's time to take another I take ibuprofen. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Lages on how often can you take 800 mg ibuprofen: No more than 3x per day, always with food in your stomach to protect the stomach lining. I was taking 400mg 4x a day for years until it ate my stomach out. I now take Naproxen 500mg 2x a day. 2 a day just do not last, can Ibuprofen be take inbetween the 2 Naproxen. It can be taken together safely. If you have any worries talk to your doctor as well as your pharmacist. Using either for a short time, you needn't worry. Personalized, quality suggestions from Doctors: Worried about negative side effects? Dr. Munshower tells you whether or not it's safe to take ibuprofen and naproxen together.