Trazodone is a prescription drug that is used for treating depression in adults. The medication is believed to work by balancing serotonin levels in the brain and blocking certain serotonin receptors. Trazodone is an oral antidepressant drug that affects the chemical messengers (neurotransmitters) within the brain that nerves use to communicate with (stimulate) each other. The FDA-approved use for trazodone is as an antidepressant, but it has many other off-label uses as well. One of the most common is as a sleep aid. Trazodone, sold under many brand names, is an antidepressant medication. It is used to treat major depressive disorder, anxiety disorders, and, with other medications, alcohol dependence. It is taken by mouth. Trazodone is an antidepressant medication that is also sometimes used off-label for the treatment of insomnia and as an adjunctive treatment for schizophrenia. Learn about the prescription drug Trazodone (Desreyl, Oleptro, Deprax), including information about its uses, dosage, side effects, and common interactions. Medical uses. Gabapentin is FDA approved to treat seizures and neuropathic pain. It is primarily administered by mouth, with a study showing that rectal administration is not satisfactory. It is also commonly prescribed for many off-label uses, such as treatment of anxiety disorders, insomnia, and bipolar disorder. About 90% of usage is for. Trazodone is an oral drug, which is available as a regular-release or extended-release tablet. The tablets have a score line, or indentation down the middle. Trazodone official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. It’s recommended with the trazodone dose for sleep that people take it at bedtime, and doses include 50, 100, 150 and 300 mg tablets. The starting trazodone dose for sleep is anywhere from 25 to 50 mg.