Nabumetone is used to reduce pain, swelling, and joint stiffness from arthritis.This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).If you are treating a chronic condition. NABUMETONE. Show all parts of this monograph; Indications and dose; Contra-indications; Cautions; Interactions; Side-effects; Allergy and cross-sensitivity; Conception and contraception; Pregnancy; Breast feeding; Hepatic impairment; Renal impairment; Medicinal forms; Indications and dose. Pain and inflammation in osteoarthritis and rheumatoid arthritis. By mouth. For Adult. 1 g once daily. Nabumetone may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using nabumetone, especially in older adults. You should not use nabumetone if you are allergic to it, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID. Nabumetone is a nonacidic NSAID prodrug that is rapidly metabolized in the liver to the active metabolite, 6-methoxy-2-naphthyl acetic acid. As found with previous NSAIDs, nabumetone's active metabolite inhibits the cyclooxygenase enzyme and preferentially blocks COX-2 activity (which is indirectly responsible for the production of inflammation and pain during arthritis). The active metabolite. 3. Liste des principaux anti-inflammatoires non stéroïdiens (AINS) Dernière mise à jour : 22-10-2018 Nabumetone may harm the fetus and cause problems with delivery if it is taken around 20 weeks or later during pregnancy. Do not take nabumetone around or after 20 weeks of pregnancy, unless you are told to do so by your doctor. If you become pregnant while taking nabumetone, call your doctor. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking. Nabumetone belongs to a class of drugs called nonsteroidal anti-inflammatory drugs ().Other members of this class include ibuprofen (), indomethacin (), naproxen and several others.These drugs are used for the management of mild to moderate pain, fever, and inflammation.They work by reducing the levels of prostaglandins, chemicals produced by the body that are responsible for pain, fever and. Nabumetone oral tablet is a prescription medication used to help reduce pain, inflammation, and swelling caused by osteoarthritis and rheumatoid arthritis. It's only available as a generic drug. Nabumetone is a white to off-white crystalline substance with a molecular weight of 228.3. It is nonacidic and practically insoluble in water, but soluble in alcohol and most organic solvents. It has an n-octanol: phosphate buffer partition coefficient of 2400 at pH 7.4. Nabumetone is contraindicated in the setting of CABG surgery. NSAIDs cause an increased risk of serious gastrointestinal (GI) adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients and patients with a prior history of.