Withdrawal from trazodone is not considered to be potentially life-threatening, although individuals who have used antidepressants for depression may be at risk for poor judgment or potential self-harm during the withdrawal period. Withdrawal from trazodone may cause sudden fatigue. Symptoms of trazodone withdrawal may include extreme irritability. Trazodone increases the level of the chemical serotonin in the brain. Fatigue: Feelings of excessive tiredness and lethargy are common, especially during the early stages of withdrawal. You may have a tough time getting up in the morning and/or mustering up the energy to be productive. Hello, I had been taking 25mg of Trazodone for the last 6 months each night for sleep and just went off of it with no taper. It has been a week for me and the occasional nausea is still here slightly and the brain fog, fatigue, and mental disorientation is hanging around too. Trazodone is an anti-depressant belonging to the class of medicines called serotonin antagonist reuptake inhibitors. It is used to treat major depression, anxiety disorders, insomnia, night mares, pain syndrome, panic disorder, obsessive compulsive disorder, diabetic neuropathy, alcohol withdrawal, eating disorders, etc. The Point of Return Trazodone Withdrawal Program is an in-home Trazodone tapering program that allows you to gradually lessen the amount of Trazodone while also implementing the use of all-natural, calming nutraceuticals to help ease symptoms. Trazodone (generic name: Desyrel ) increases the amount of a brain chemical called serotonin and is indicated for the treatment of major depressive disorder. Trazodone Trazodone HCl (generic Desyrel) is a modified cyclic antidepressant used as a treatment for depression. It may also be used for relief of an anxiety disorder (e.g., tension, sleeplessness), chronic pain or to treat other conditions as determined by your doctor. When my sleep returned to normal I stopped taking Trazodone and I did not notice any WITHDRAWAL effects at all. NONE. But if they are a problem just taper. Unlike the SSRI Cipralex which did cause me brain zaps when I stopped. I did not find Cipralex any trouble to stop with rapid tapering. Trazodone, also sold under the brand name Desyrel, is an antidepressant medication prescribed for the treatment of neuropsychiatric disorders such as: major depressive disorder, generalized anxiety disorder, and insomnia.