Hi all, So this was my first round of clomid. I am pretty sure I ovulated last tuesday or wedensday. Since yesterday my breasts have been really sore.this morning they were actually painful. Some of the side effects from Clomid are: mood swings, depression, increase appetite, headaches, dizziness, tiredness, acne, painful ovulation, earlier or later ovulation than usual. We have been trying to get pregnant for a while. This was my first cycle on clomid (days 5-9, 50mg). My last period began on August 1. I have been so sick to my stomach and my breast/nipples are extremely tender. yes its could be from the clomid i took it and i had bad cramps and sore boobs but the hot flashes were the worst Can Clomid cause Breast Lumps? Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. Can Clomid cause Breast Pain? Breast Pain is a known side effect of Clomid. Complete analysis from patient reviews and trusted online health resources, including first-hand experiences. - Page 2 Breast Pain is a known side effect of Clomid. Doctors give unbiased, trusted information on whether Clomid can cause or treat Breast Pain: Dr. Burns on sore breasts clomid: Don't guess. Take a test. In today's world you do not need to wonder if you are pregnant or not based on symptoms. Pregnancy tests are available at any pharmacy and in minutes you will have your answer. They can detect a pregnancy 7-10 days after conception. The best. Clomid may cause one or both ovaries to become enlarged. This may happen during or shortly after a five-day trial. This enlargement may be noticed on examination or the woman may notice that her abdomen feels bloated and swollen. I am on my first cycle of clomid (day 22) and I have been having some intense lower abdominal pain, bloating, and cramping. It seems to get worse as the day progresses (in the morning's it doesn't hurt as bad). It’s important to track the cause of it. But know that. and cysts (fluid-filled sacs) form in your breasts. It can be painful, but it’s normal and usually harmless. About half of women in.