Headaches, dizziness and irritability accompany the abrupt withdrawal of Seroquel. Neurological brain chemicals normally can work together with antipsychotic and antidepressant medications, easing symptoms of mental illness. Quetiapine, sold under the trade name Seroquel among others, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder. [6] [7] Although not recommended, it is also used as a sleep aid due to its sedating effect. [8] Seroquel Withdrawal Syndrome The appearance of the side effects is possible because the time is needed for the brain to adjust to the new conditions. These side effect are not a result of Seroquel abuse or because it is addictive. Seroquel does affect the central nervous system, including the serotonin and dopamine receptor sites, which is why it’s believed to cause withdrawal if someone tries to stop using it suddenly. Some antipsychotic withdrawal symptoms can include nausea, tachycardia, headache and anxiety. Seroquel Withdrawal Syndrome Seroquel is not addictive and there are almost no chances of Seroquel abuse; but the brain may not be able to adjust to a sudden drop in the levels of Seroquel. Stopping the medicine abruptly affects the functioning of brain and the bodily systems. Seroquel Withdrawal Symptoms: List of Possibilities Below are a list of common symptoms that have been reported during Seroquel withdrawal. Keep these symptoms in mind when you come off of the medication so that you know what to expect. Summary. Withdrawal syndrome is found among people who take Seroquel, especially for people who are female, 50-59 old , have been taking the drug for 2 - 5 years, also take medication Xanax, and have Depression. The timeline along which the symptoms of Seroquel withdrawal will develop will also vary significantly from person to person based on the same issues that impact the type of withdrawal symptoms experienced. For example, some may experience minimal withdrawal symptoms for a week or two after they stop taking a low dose of Seroquel. With higher doses, the withdrawal syndrome may be more severe. Seroquel Withdrawal Symptoms Seroquel helps to stabilize brain chemistry by blocking the chemical receptors of serotonin, dopamine and adrenergic. The brain becomes used to having a high level of these natural chemicals within the brain at all times. Seroquel (Quetiapine) Withdrawal Symptoms As is the case for most prescription psychoactive medications, using them for some extended period of time, i.e. several months or longer may lead to physical dependence.