How to use Mucinex. Take this medication by mouth with or without food, as directed by your doctor, usually every 12 hours with a full glass of water. Summary. Drug interactions are reported among people who take Mucinex dm and Xanax together. This study is created by eHealthMe based on reports of 34 people who take Mucinex dm and Xanax from FDA, and is updated regularly. Summary. Drug interactions are reported among people who take Xanax and Mucinex together. This study is created by eHealthMe based on reports of 700 people who take Xanax and Mucinex from FDA, and is updated regularly. Many other products contain the same ingredients as Mucinex D, so you should read labels carefully to make sure you're not taking too much guaifenesin or pseudoephedrine by combining drugs. As of 2015, Mucinex, which is guaifenesin, has no known drug interactions, according to Drugs.com. However, individuals should consult their doctors or pharmacists when taking this medication, because an unknown drug interaction may exist. AlaskaONE is the original internet based Alaska travel guide. AlaskaONE lists 100's of independent Alaska businesses of all sizes. AlaskaONE is your resource to learn about Alaska's diverse Parks & Places. There is no known interaction between Mucinex and Xanax in our records. However, an interaction may still exist. However, an interaction may still exist. Always consult your doctor before taking these medications together. Does Mucinex D Tablet, Extended Release 12 Hr Interact with other Medications? Severe Interactions. These medications are not usually taken together. Can I take Mucinex with Xanax? There is no known interaction between Mucinex and Xanax in our records. However, an interaction may still exist. - Page 2 Commenter Name Nordstrom, D, Lindy, O, Lauhio, A, Sorsa, T, Santavirta, S, Konttinen, YT, Anti-collagenolytic mechanism of action of doxycycline treatment in.