One of the two biggest problems with mixing opioid painkillers like Vicodin or oxycodone with benzodiazepines like Xanax or Valium is the issue of oversedation. Withdrawal from Dilaudid and Alcohol. Withdrawal from Dilaudid and alcohol produce very different symptoms and risks. Consequently, the treatment of dependence and addiction to Dilaudid and alcohol is more complicated. Recommended prescription doses of oxycodone and hydrocodone cause drowsiness. Taking these drugs together exaggerates this effect, especially if they are taken in amounts greater than the recommended dose. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Rosenfeld on oxycodone side effects in elderly: Propofol causes hypotension. All effects are dose dependent and patient dependent. Your anesthesiologist will adjust the dose based on multiple factors including age. Potential Side Effects Of Mixing Alcohol And Zoloft. Typically, consuming multiple substances at once, or polydrug abuse, can increase the risk of adverse interactions. Mixing alcohol with any opiate drug, including Suboxone, can be an extremely dangerous and even lethal practice. So what should you know about mixing alcohol and Flagyl? Is it safe to take metronidazole after drinking alcohol? If you’re wondering is it safe to take metronidazole after drinking alcohol, it’s important to know the possible side effects. Learn about the dangers of mixing Ativan with alcohol, opiates and more here. If you have a problem with Ativan abuse, call Michael's House for help today. Effects Of Mixing Alcohol And Energy Drinks. The spike in the popularity of energy drinks has created a new trend in nightlife- combining energy drinks with alcohol. With almost any medicine someone takes, there can be things to ensure you’re aware of, and also interactions and side effects of mixing it with other substances.