Can I take Nexium and Synthroid (generic of synthroid) at the same time in the morning? Both have to be taken in the morning on an empty stomach, an hour or so before a meal. We use cookies to give you the best possible experience on our website. By continuing to use this site you consent to the use of cookies on your device as described in our I was told by my doctor that Synthroid and Nexium can be taken at the same time (and I do with never a change in my TSH). Synthroid is absorbed in the stomach. It can often be difficult to plan appropriate administration times for medications that require specific dosing times to be effective. This is certainly the case for Synthroid (levothyroxine) and Nexium (esomeprazole). Can levothyroxine and nexium be taken at the same time (before breakfast)? Updated 3 Apr 2011 • 1 answer Is it O.K. to take Lisinopril and Synthroid at the same time 1 hour before eating breakfast? Can I take Nexium and Synthroid (generic of synthroid) at the same time in the morning? Both have to be taken in the morning on an empty stomach, an hour or so before a meal. Although there are no known interactions between levothyroxine and Nexium. I would avoid taking them at the same time. Take the levothyroxine first and give it time to be absorbed. Joy, You may be right about not being able to take them together. I have one med that I can take with my Synthroid, but I cannot take my supplements at the same time as my Synthroid.