You can overdose on ibuprofen. You should always take it exactly as directed on the label or as recommended by your doctor. Taking too much ibuprofen, which is called an overdose, can cause. I had a headache and took 6 ibuprofen pills. Will i die or be really sick? And how many would it take to kill you? Therefore, you can’t use any anti-inflammatory medication for at lease six months after the ibuprofen overdoes. There are some medication that can’t be use at the same time with any anti-inflammatory medication such as some blood pressure medications. You bet you can. (400mg/kg) is very toxic. That’s about 150 pills of 200mg strength. The effect of ibuprofen in overdose is rather lengthy so I copied this from Wikipedia. (400mg/kg) is very toxic. That’s about 150 pills of 200mg strength. Tylenol, Tylenol is what's gonna give you liver failure pretty fast and after roughly 2weeks or so of hospitalization you'll most likely pass away if docs can't find a new liver in time. If you need to take ibuprofen more often, talk to your doctor about medication alternatives. Your doctor may recommend a painkiller that does not interfere with the effect of low-dose aspirin. Your doctor may recommend a painkiller that does not interfere with the effect of low-dose aspirin. If you are given medical treatment quickly you can expect to recover from an ibuprofen overdose, but it should be noted that you are at risk for serious or life threatening medical conditions. When being treated for an overdose your doctor will evaluate your condition and prescribe an appropriate course of action. All drugs, including the ibuprofen in Advil, have a lethal dose. It is estimated by the Royal College of Physicians that 400 milligrams per kilogram (a little over 180 milligrams per pound) of ibuprofen could kill a person. 1. Knowing how many ibuprofens does it take to die and what overdose of it can do for you is not enough, know also what to do if overdose. Call the Poison Help line (1-800-222-1222) and seek emergency medical attention.