Mixing alcohol and drugs is never a good idea. Whether they are over-the-counter prescription meds or illegal drugs, taking them with booze can have fatal consequences. How to Safely Detox from Drugs or Alcohol at Home. Home detox from drugs or alcohol can be an appealing option for addicts who don’t want to commit the time and money to an actual rehab treatment plan. The fact is, mixing medication with alcohol can be dangerous to your health. Alcohol can interfere with some drugs, making them less effective. Mixing these two medications can be dangerous. The short answer is to not overdo it. Taking the manufacturer's recommended dosage of aspirin and acetaminophen together for a short time has not been shown to cause organ damage. Mixing Adderall with alcohol is a dangerous practice. Find out how the combination can influence behavior and health and lead to alcohol poisoning. DIY 16 Common Product Combinations You Should Never Mix. Chemistry is an insane thing. And what you don't know could kill you. PKIDs’ PHR 291 IBUPROFEN vs. ACETAMINOPHEN IBUPROFEN vs. ACETAMINOPHEN Which Painkiller is Better for Children with Viral Hepatitis? Adults and children with chronic viral hepatitis suffer the same fevers, colds and body You can indeed take both of these medications at the same time, and in fact your doctor may recommend that you do so. These drugs do not exhibit any inherent, dangerous interaction with each other. Medical professionals often research and warn against the dangers of polydrug use, or the ingestion of more than one type of drug. While polydrug use often centers on substances like alcohol, heroin, cocaine, or marijuana, there is a growing trend of mixing prescription medications for recreational purposes. Most of us are aware of the dangers of mixing alcohol with other depressants like tranquilizers, but the labels on almost all over-the-counter pain relief medications contain warnings concerning their use along with the use of alcohol.