There are several risks associated with epidural injections, and although they are all relatively rare, it is worth discussing each with the professional who will be conducting the procedure to determine the incidence of prevalence in their practice. Prednisone and other corticosteroid pills, creams and injections can cause side effects. Find out what to expect. Find out what to expect. Are you using a corticosteroid? Prednisone is used to treat allergic disorders, ulcerative colitis, psoriasis and arthritis. Learn about side effects, interactions and indications. Learn about side effects, interactions and indications. Cortisone injections are very safe to perform. Side effects tend to be rare and minor. However, there are a few things you should understand before having an injection of this medication. Prednisone is a popular drug recommended by doctors for treating a wide range of medical conditions. Its primary therapeutic effect is to reduce the body's immune responses, and is administered after organ transplantation. PREDNISONE Tablets, USP. DESCRIPTION. Prednisone tablets, USP contain prednisone which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Steroid injections reduce the effect of your body’s immune system in the short term. This is how they reduce inflammation. This is how they reduce inflammation. Some vaccines work by giving you a very small dose of a particular disease, so that you then become immune to it. The prescribing information does not list muscle cramps as a common side effect of prednisone. The most common short-term side effects are stomach upset, headaches, insomnia, and irritability. The. Is sunburn a side effect of prednisone? Should I avoid being in the sun while taking prednisone? Should I avoid being in the sun while taking prednisone? Are there any drug interactions between prednisone and Viagra? Find patient medical information for Prednisone Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.