If concomitant use of amiodarone with sofosbuvir and daclatasvir, simeprevir and sofosbuvir, or sofosbuvir and ledipasvir cannot be avoided because other anti-arrhythmics are not tolerated or contraindicated, patients should be closely monitored, particularly during the first weeks of treatment. Introduction Amiodarone is a potent arrhythmia suppressing agent that has been clearly linked to several distinct forms of drug induced liver disease. Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of irregular heartbeats. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia. Evidence in cardiac arrest, however, is poor. It can. Read about amiodarone (Cordarone, Nextrone, Pacerone), a drug used for many serious arrhythmias of the heart including ventricular fibrillation, ventricular tachycardia, atrial fibrillation, and atrial flutter. Side effects, drug interactions, dosing and storage information, and pregnancy information is included. ALERT: U.S. Boxed Warning Life-threatening arrhythmias (tablet): Amiodarone is intended for use only in patients with indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity. WARNING: PULMONARY, HEPATIC and CARDIAC TOXICITY. Amiodarone hydrochloride tablets is intended for use only in patients with the indicated life-threatening arrhythmias because its use is accompanied by substantial toxicity [see Indications and Usage (1)]. Background Whether antiarrhythmic drugs improve the rate of successful resuscitation after out-of-hospital cardiac arrest has not been determined in randomized clinical trials. Methods We. DESCRIPTION. CORDARONE (amiodarone HCl) is an antiarrhythmic drug, available for oral administration as pink, scored tablets containing 200 mg of amiodarone hydrochloride. Antiarrhythmic drugs are used commonly in out-of-hospital cardiac arrest for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia, but without proven survival benefit. In. Click here for Frequently Asked Questions on Amiodarone. Amiodarone is a medication commonly used to treat patients with irregular heart beats, or cardiac arrhythmias.