Most research shows both treat pain equally, and they both usually take effect within anywhere from 30 to 60 minutes. However, oxycodone is more associated with constipation than hydrocodone. However, oxycodone is more associated with constipation than hydrocodone. Made with only pure hydrocodone and no Tylenol or acetaminophen, the pill is easily crushed, making it easier to abuse. According to Dr. Jim Keany of St. Joseph's Hospital in Orange County , one. Heroin. Heroin remains one of the most popular and powerful opiates in the world. And even with the release of potent opiate-based painkillers, heroin still remains dangerously addictive. Vicodin is just 5/500, sometimes 7.5/750 which are Vocodin ES, but avoid taking those they have the biggest amounts of Tylenol. You can request your doc to give you something with less Tylenol, which would be Norco, that comes in different strengths, 5/325, 7.5/325, and the 10/325. The agency said Friday it approved the extended-release pill Zohydro ER for patients with pain that requires daily, around-the-clock, long-term treatment that cannot be treated with other drugs. Uses. This combination medication is used to relieve moderate to severe pain. It contains an opioid pain reliever (hydrocodone) and a non-opioid pain reliever (acetaminophen). Oxycodone and hydrocodone are powerful narcotic painkillers. Both are available only with a prescription from your doctor. Both interfere with your central nervous system’s pain signals. a list of least powerful to most powerful please i need answers soon thanks! Tramadol and hydrocodone are two types of potent pain relievers called opioid analgesics. They’re often used to treat moderate to severe pain, such as long-term pain related to cancer or other. To answer your question a 7.5 mg hydrocodone pill is not strong at all! I don’t even think that it would greatly effect a person with no previous experience with opiates. I don’t even think that it would greatly effect a person with no previous experience with opiates.