You should only take one medicine containing acetaminophen at a time. Click here to learn more about taking medicine responsibly. Aleve and Tylenol are over-the-counter brands of different pain medications. People frequently use them to treat mild complaints, such as headaches and sore throats. Aleve and Tylenol are safe to. Use Only as Directed About 150 Americans a year die by accidentally taking too much acetaminophen, the active ingredient in Tylenol. The toll does not have to be so high. Learn about Tylenol (Acetaminophen) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. I realize this was posted 3+ years ago, but there needs to be another voice here. Tylenol by itself, look at taking 2 extra strength Tylenols, twice a day, not too much damage there, in fact probably not much if a lot of water is consumed. If you have ever had strep throat, you probably remember the experience as one of the worst sore throats of your life. Strep throat is an infection in your throat, and the cause is the bacterium Streptococcus pyogenes which is Group A Streptococcus, not viral. TYLENOL® works fast to relieve head and body aches and won't irritate your stomach the way that aspirin, naproxen sodium, or even ibuprofen can. Tylenol is associated with serious complications, including liver damage and rare but dangerous skin reactions. It is the leading cause of acute liver failure in the U.S., and the drug in some cases led to fatalities. Yesterday I purchased Tylenol arthritis.I have been taking perscription antiflammitories for years. My issue with inflammatory medication is does nothing for pain in my case anyways. SHOULD I TAKE TYLENOL, ADVIL OR ASPIRIN? by eugeneyeung. When I work as a pharmacist in a retail pharmacy, I get a lot of questions from customers on which painkiller is best for them.