Nabumetone, like all NSAIDs, may exacerbate hypertension and congestive heart failure and may cause an increased risk of serious cardiovascular thromboembolism, myocardial infarction, and stroke, which can be fatal. Learn about Relafen (Nabumetone) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as nabumetone may have a higher risk of having a heart attack or a stroke than people who do not take these medications. Nabumetone oral tablet can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. Pregnancy-FDA pregnancy category C. This means that it is not known whether aspirin/butalbital/caffeine will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is used to treat arthritis. It may be given to you for other reasons. Talk with the doctor. What do I need to tell my doctor BEFORE I take Nabumetone? Most patients, benefit from nabumetone and other NSAIDs with few side effects. However, serious side effects can occur, and generally tend to be dose-related. [FDA strengthens warning that non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) can cause heart attacks or strokes (FDA Drug Safety Communication). Based on FDA’s comprehensive review of. Uses. Nabumetone is used to reduce pain, swelling, and joint stiffness from arthritis. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). Important Information. Nabumetone can increase your risk of fatal heart attack or stroke, especially if you use it long term or take high doses, or if you have heart disease.