Commonly Observed The more commonly observed untoward events associated with the use of BuSpar not seen at an equivalent incidence among placebo-treated patients include dizziness, nausea, headache, nervousness, lightheadedness, and excitement. Our Buspar Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. This is not a complete list of side effects and others may occur. Consumer information about the medication BUSPIRONE - ORAL (Buspar), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug BUSPIRONE - ORAL. BUSPAR (buspirone hydrochloride) Tablets. DESCRIPTION. Buspirone hydrochloride tablets, USP are an antianxiety agent that is not chemically or pharmacologically related to the benzodiazepines, barbiturates, or other sedative/anxiolytic drugs. Along with its needed effects, buspirone (the active ingredient contained in BuSpar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. BuSpar (buspirone) is an anti-anxiety medicine that affects chemicals in the brain that may be unbalanced in people with anxiety. BuSpar is used to treat anxiety disorders or the symptoms of anxiety, such as fear, tension, irritability, dizziness, pounding heartbeat, and other physical symptoms. Buspirone, sold under the brand name Buspar among others, is a medication primarily used to treat anxiety disorders particularly general anxiety disorder. Benefits are support for short term use. It is not useful for psychosis. It is taken by mouth. It may take up to four weeks for an effect. Common side effects include nausea, headaches, dizziness, and trouble concentrating. Serious side. Buspirone Warnings. You should not take buspirone if you are taking a monoamine oxidase inhibitor (MAOI), a type of drug used for treating depression. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Buspar is used for the management of anxiety disorders or the short-term relief of anxiety symptoms and is commonly prescribed in drug rehab centers.