As Seroquel has several indications, the safety profile should be considered with respect to the individual patient's diagnosis and the dose being administered. Find information to better understand major depressive disorder (MDD), bipolar disorder, bipolar depression, and SEROQUEL XR® (quetiapine fumarate). Hi Deb, If you have only been taking seroquel for a short time you should be fine stopping it. However, if you start having withdrawals you may want to take your regular dose one night the next night skip the dose then go two nights without it and continue on with that pattern or you may want to cut the 25 mg with a pill cutter and decrease. Quetiapine, sold under the trade name Seroquel among others, is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, and major depressive disorder. Seroquel is the brand name of the generic drug quetiapine, used to treat schizophrenia and bipolar disorder (formerly known as manic-depression). Seroquel, also known by its generic name quetiapine, is an atypical antipsychotic medication that blocks dopaminergic transmissions, resulting in less overall excitement in the brain. Warning There is a higher chance of death in older adults who take Seroquel (quetiapine tablets) for mental problems caused by dementia. MEDGUIDE SECTION Medication Guide SEROQUEL (SER-oh-kwell) (quetiapine fumarate) Tablets. Read this Medication Guide before you start taking SEROQUEL and each time you get a refill. What is Seroquel? Seroquel is brand name for the generic drug Quetiapine and is a second generation atypical antipsychotic medication produced by AztraZeneca. SEROQUEL 25 mg, 100 mg, 200 mg, 300 mg film-coated tablets - Patient Information Leaflet (PIL) by AstraZeneca UK Limited.