Prednisone and prednisolone are two common treatments for ulcerative colitis. These drugs are similar, but they're not the same. Find out how they differ. I barely noticed any side effects honestly, and I was quite nervous because of all the reviews online. I maybe felt a little jittery the first day, but that may have just been anticipatory anxiety. I maybe felt a little jittery the first day, but that may have just been anticipatory anxiety. Check out other treatments for ulcerative colitis and other treatments for Crohn's disease Other Considerations Because prednisone can increase the risk of osteoporosis, it is advisable to take 1500mg of Calcium and 1000u of Vitamin D daily while taking this medication. Ulcerative colitis is a chronic inflammatory disease of the colon with an increasing incidence worldwide. The medical management of this disease continues to expand as drugs to induce and maintain remission are sought to avoid the need for colectomy. I took prednisone for severe flare of UC, it worked immediately.I didn't experience serious side effects while taking it, only sleep deprivation, shaking hands. I'd like to know your experience with prednisone. I've tried most of the 5 ASAs with no help. My doctor wants me on prednisone but I'm terrified of the side effects (hair loss, moon face, acne, weak immune system, joint problems, and every other darn thing). I was recently diagnosed with UC and my doctor wants me to start taking prednisone for 6 weeks to get it under control. My doctor described side effects of prednisone to me, including insomnia, weight gain, manic depression, acne, as well as several others. Prednisone is a drug that is commonly used to treat many inflammatory conditions. It is often prescribed to treat the two major forms of inflammatory bowel disease (IBD)—Crohn's disease and ulcerative colitis. Prednisone is used to treat allergic disorders, ulcerative colitis, psoriasis and arthritis. Learn about side effects, interactions and indications. Medication indication. NOTE: This medication has been typically used for the treatment of ulcerative colitis and also Crohn's disease. Talk to your doctor about potential risks and side effects.