Consumer information about the medication TRETINOIN CREAM - TOPICAL (Renova), includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug TRETINOIN CREAM - TOPICAL. SIDE EFFECTS (See WARNINGS and PRECAUTIONS sections.) In double-blind, vehicle-controlled studies involving 179 patients who applied RENOVA (tretinoin emollient cream 0.05%) 0.05% to their face, adverse reactions associated with the use of RENOVA (tretinoin emollient cream 0.05%) 0.05% were limited primarily to the skin. Your doctor may want you to stop using tretinoin cream for some time, change how much you use, or change how often you use tretinoin cream. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Tretinoin Cream USP, 0.05% is used for the topical treatment of acne vulgaris. Tretinoin Cream contains tretinoin in 0.05% by weight, in a hydrophilic cream vehicle of butylated hydroxytoluene, isopropyl myristate, polyoxyl stearate type II, purified water, sorbic acid, stearic acid, stearyl alcohol and xanthan gum. SIDE EFFECTS (See WARNINGS and PRECAUTIONS sections.) In double-blind, vehicle-controlled studies involving 339 patients who applied RENOVA® (tretinoin cream) 0.02% to their faces, adverse reactions associated with the use of RENOVA® (tretinoin cream) 0.02% were limited primarily to the skin. Tretinoin Cream, USP (Emollient) 0.05% contains the active ingredient tretinoin in a cream base. Tretinoin is a yellow-to-light-orange crystalline powder having a characteristic floral odor. Tretinoin is soluble in dimethylsulfoxide, slightly soluble in polyethylene glycol 400, octanol, and 100% Tretinoin cream can cause such harmful side effects as changes in your skin color, sores, blisters and crusting of your skin, says MedlinePlus. It may also cause intense redness and swelling. Discontinue retinoin and call your doctor immediately. How to use Tretinoin 0.025 % Topical Cream. Read the Patient Information Leaflet if one is available from your pharmacist. Consult your doctor or pharmacist if you have questions. Tretinoin Cream, USP a topical retinoid, contains tretinoin USP, 0.025% by weight in a hydrophilic cream vehicle of stearic acid, polyolprepolymer-2, isopropyl myristate, polyoxyl 40 stearate, propylene glycol, stearyl alcohol, xanthan gum, sorbic acid, butylated hydroxytoluene, and purified water. Its cream contains either of the three strength of 0.025%, 0.05% and 0.1% by weight. The optimal percentage of tretinoin to be used depends with the sensitivity of your skin and the type of the problem to be treated.