Before taking this medicine. You should not use this medicine if you are allergic to levofloxacin or other fluoroquinolones (ciprofloxacin, gemifloxacin, moxifloxacin, norfloxacin, ofloxacin, and others). If you are taking didanosine buffered tablets for oral suspension or the pediatric powder for oral suspension, sucralfate, or antacids, multivitamins, or other products containing aluminum, magnesium, iron, or zinc, take them at least 2 hours before or 2 hours after using levofloxacin. These medicines may keep levofloxacin from working properly. How to use Levofloxacin. Read the Medication Guide provided by your pharmacist before you start taking levofloxacin and each time you get a refill. Taking nonsteroidal anti-inflammatory drugs with levofloxacin may increase the risk of central nervous stimulation, resulting in over-excitation. There have been reports of changes in blood sugar (increases and decreases) in patients treated with fluoroquinolones and antidiabetic agents. Taking levofloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. Taking levofloxacin with certain medications raises your risk of side effects from those drugs. Examples of these drugs include: Insulin and certain oral diabetes drugs, such as nateglinide. Drug Information on Levaquin, Levaquin Leva-Pak (levofloxacin (oral)) includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid. Stop taking levofloxacin and call your doctor at once if you have sudden pain, swelling, bruising, tenderness, stiffness, or movement problems in any of your joints. Before taking this medicine You should not use Levaquin if you are allergic to levofloxacin or other fluoroquinolones ( ciprofloxacin , gemifloxacin , moxifloxacin , norfloxacin , ofloxacin , and others).