If the meds survive, they earn themselves an expiration date between 12 and 24 months from the date of manufacture, depending on the degree of decomposition during the testing. Thus that date guarantees the drug will still work during that time period--but it says nothing about whether it will work after that period ends. Most medications have an expiration date between 12 to 60 months after they are manufactured. If a pharmacist puts your medication into another container, that date will be even shorter and is reflected in the beyond-use date. The effects of Zoloft may last for some days after you have stopped taking it. Side effects Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Zoloft. She checks the expiration date on everything before she eats because she is scared of eating something expired and throwing up.She even got anxiety in a restaurant the other night as soon as we walked in and she smelled the food. She was put on zoloft 25 mg about 3 mo ago. Her dr sent her to a therapist but that with medicine didn't really help. Taking a drug after the expiration date is taking a chance that it won't be as effective as a drug taken within the guaranteed effective. So, in answer to your question, on the. If you have the bottle call the pharmacy and they can tell you by the expiration date on the bottle what the remainder of the shelf life is. I would NOT take an expired medication especially anti-depressants anti-anxiety drugs. what good are they if you only have some. What they found from the study is 90% of more than 100 drugs, both prescription and over-the-counter, were perfectly good to use even 15 years after the expiration date. So the expiration date doesn't really indicate a point at which the medication is no longer effective or has become unsafe to use. Sertraline - how long after the expiration can you still use your prescription? Asked 6 Oct 2015 by RDH 215 Updated 6 October 2015 Topics depression, sertraline, prescription, expiration There was recently a government publication that indicates that expiration dates may be too short and that medication remains viable for a much longer time. Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Colantino on does zoloft expire: There should be a date on the container.