Misoprostol helps to decrease your risk of serious ulcer complications such as bleeding. This medication protects your stomach lining by lowering the amount of acid that comes in contact with it. bleeding, will need to use misoprostol as scheduled to complete the abortion. After administration of After administration of misoprostol, bleeding usually starts from 1/2 hour to 10 hours later (with the average being 2-4 hours), and Misoprostol Tablets may produce uterine contractions, uterine bleeding, and expulsion of the products of conception. Abortions caused by Misoprostol Tablets may be incomplete. If a woman is or becomes pregnant while taking this drug to reduce the risk of NSAID-induced ulcers, the drug should be discontinued and the patient apprised of the potential hazard to the fetus. Misoprostol is relatively metabolically resistant and thus has prolonged action. Misoprostol is absorbed through mucosal surfaces and thus can be administered through a number of different routes. Misoprostol is absorbed through mucosal surfaces and thus can be administered through a number of different routes. Mifepristone alone usually does not cause any side effects before taking Misoprostol, although some women may experience light bleeding or nausea. Misoprostol can cause birth defects, premature birth, uterine rupture, miscarriage, or incomplete miscarriage and dangerous uterine bleeding. Do not use misoprostol if you are pregnant. If you are able to become pregnant, you will need to have a negative pregnancy test before starting this treatment. Bleeding after surgical abortion. Apart from using medications (mifepristone, methotrexate, and misoprostol) to terminate a pregnancy, you may sometime require the use of surgery to clear your womb completely. Women treated with misoprostol had higher rates of nausea, prolonged bleeding, and unplanned surgery, but roughly 95% (1,280 out of 1,355) were able to avoid having an invasive surgical procedure. Bleeding for 2 weeks after vaginal misoprostol for EPF is common. Heavy bleeding is usually limited to a few days after treatment. Clinically important changes in haemoglobin after misoprostol use are rare. Though uncommon, delayed episodes of prolonged or heavy bleeding requiring D&C can occur following medical management of EPF. Prolonged vaginal bleeding or spotting can occur for up to two weeks. Taking it orally can have side effects that include abdominal pain, nausea, vomiting, chills, and diarrhea. Taking it orally can have side effects that include abdominal pain, nausea, vomiting, chills, and diarrhea.