Wellbutrin and Alcohol. Reports of worsening psychiatric or neurological conditions or lowered alcohol tolerance in patients who drink while on Wellbutrin have been rare. The safety and efficacy of bupropion for smoking cessation is not established in children or adolescents. Children 6 years and older with a major depressive episode or attention-deficit hyperactivity disorder (ADHD) have been studied in clinical trials of bupropion, but data regarding pediatric safety are limited. Wellbutrin XL is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. The Zyban brand of bupropion is used to help people stop smoking by reducing cravings and other withdrawal effects. Wellbutrin (bupropion) is an antidepressant medication used to treat major depressive disorder and seasonal affective disorder. Wellbutrin may also be used for purposes not listed in this medication guide. How to Stop Taking Wellbutrin. Wellbutrin, or bupropion, is classified as an antidepressant and is usually used to treat depression—though, the drug is also used as a smoking cessation aid under the name Zyban. Since Wellbutrin affects b. Find patient medical information for Wellbutrin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Pictures of Wellbutrin (Bupropion Hcl), drug imprint information, side effects for the patient. Bupropion is an antidepressant medication approved for the treatment of major depressive disorder and seasonal affective disorder (SAD). DESCRIPTION. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Please click here or scroll down for Important Safety Information, including a Boxed Warning regarding suicidal thoughts and actions with antidepressant medicines.