History. Acetone was first produced by alchemists during the late Middle Ages via the dry distillation of metal acetates (e.g., lead acetate, which produced spirit of Saturn (since the alchemical symbol for lead was also the astrological symbol for the planet Saturn)). Chloramphenicol is an antibiotic that is clinically useful for, and should be reserved for, serious infections caused by organisms susceptible to its antimicrobial effects when less potentially hazardous therapeutic agents are ineffective or contraindicated. Pharmacotherapeutic group (AITC code): S01 AA01, antibiotics for topical use. Chloramphenicol is a broad spectrum antibiotic which has activity against many types of Gram-positive and Gram-negative bacteria. Chloramphenicol is a broad spectrum bacteriostatic antibiotic. It is active against a wide range of Gram-negative and Gram-positive organisms, including Salmonella typhi, Haemophilus influenzae, Neisseria meningitidis, Streptococcus pneumoniae and Bacteroides fragilis. UKPAR Chloramphenicol 0.5% w/v antibiotic eye drops PL 16028/0131-2 6 2.5 Manufacturers The proposed manufacturing site is consistent with that registered for the cross- Todar's Online Textbook of Bacteriology contains 46 chapters on bacteria including structure-function, growth, metabolism, interactions with humans, antimicrobial agents, antibiotic resistance, pathogenesis and medically-important species. Biochem/physiol Actions Mode of Action: Chloramphenicol inhibits bacterial protein synthesis by blocking the peptidyl transferase step by binding to the 50S ribosomal subunit and preventing attachment of aminoacyl tRNA to the ribosome. Antibacterial MedChem Express HY-B0239: Anti-infection MedChem Express HY-B0239: Anti-infection; MedChem Express HY-B0239: Chloramphenicol is a broad-spectrum antibiotic. Application Chloramphenicol is a synthetic antibiotic, isolated from strains of Streptomyces venezuelae. It is often used for bacterial selection in molecular biology applications at 10-20 μg/mL and as a selection agent for transformed cells containing chloramphenicol reistance genes. External links. FAO Food and Nutrition Papers Overview at World Health Organization - Food and Agriculture Organization (1997). Raymond J, Boutros N, Bergeret M (2004).