Proton pump inhibitors include such well-known brands such as Prilosec, Nexium, Prevacid and others. Proton pump inhibitors increase the risk of heart attack in the general population by about 15. The widely used drugs known as proton pump inhibitors, or P.P.I.’s — gastric reflux preventives like Prilosec and Prevacid — may increase the risk for heart attack, according to analysis of data involving almost three million people. Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel anxious or light-headed. Prilosec Heart Attack Risk On June 10, 2015, the journal PLOS One published research from a team of doctors at Stanford University who used data mining to examine the records of 3 million patients to evaluate the potential risk of heart attacks associated with Prilosec and other PPIs. Aug. 9, 2007 -- The FDA today reported that so far, it has found no signs of heart risks associated with long-term use of the drugs Prilosec and Nexium. Prilosec heart attack – Prilosec, Nexium Side Effects: Acid Reflux Medication Heart Attack Class Action Lawsuit Investigation. Prilosec and Nexium are popular medications used to treat acid reflux disease. 18% of the studied population was made up of patients prescribed H2-blockers as treatment for heartburn or ulcers. Clopidogrel, a blood thinner used to prevent stroke, heart attack, and other heart condition among an at risk population, made up 6% of the studied group. Indigestion pills taken daily by millions raise the risk of having a heart attack, doctors fear. A major study showed that those who take proton pump inhibitor, or PPI, drugs are around 20 per. If you have any chest pain that lasts for more than a few minutes or any warning signs of a heart attack (for example, pain spreading to the arms, neck, or shoulders with shortness of breath, sweating, or lightheadedness), seek immediate medical attention. Some heartburn drugs may boost risk of heart attack, study finds Jun 10 2015 Stanford researchers found an association between a commonly used drug for treating heartburn and the likelihood of incurring a heart attack down the road.