Find patient medical information for Prilosec OTC Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Prilosec (Omeprazole) is used to treat symptoms of gastroesophageal reflux disease (GERD), erosive esophagitis and Zollinger-Ellison syndrome. PRILOSEC Packets are a once-a-day prescription treatment for heartburn and other symptoms of erosive esophagitis due to GERD for patients who have trouble swallowing pills. Table 2: Recommended Dosage Regimen of Prilosec in Pediatric Patients by Indication * The efficacy of Prilosec used for longer than 8 weeks in patients with EE has not been established. Omeprazole, approved by the FDA, is available as a prescription and over-the-counter (OTC) drug used as a treatment for frequent heartburn. Learn about side effects, drug interactions, dosages, warnings, and more. Prilosec is a proton pump inhibitor that decreases the amount of acid produced in the stomach. Prilosec is used to treat symptoms of gastroesophageal reflux disease and other conditions caused by excess stomach acid. Find out why Prilosec is the 1 doctor recommended medicine for frequent heartburn. Goodbye heartburn, hello relief. Learn about Prilosec (Omeprazole) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications. Frequently Asked Questions for Healthcare Professionals. Here are answers to common questions that you and your patients may have about Prilosec OTC. Prilosec is a heartburn medication available in both over-the-counter and prescription strengths. Drugs.com says that this medication is not suitable for immediate heartburn relief but is rather a preventive measure against symptoms of gastroesophageal reflux disease, or GERD.