Development and stability assessment of liquid paediatric formulations containing sildenafil citrate 383 Azevedo Campos, Portugal. The final solution was Original Article Physicochemical and Microbiological Stability of Phenytoin Sodium Extemporaneous Suspension. extemporaneous oral liquid suspensions should be easily prepared, allow dosage flexibility and ensure palatability. The commercially available suspending vehicles, eg. Ora-Sweet®, Ora-Sweet SF®, Ora-plus®, Ora-Blend® and SyrSpend SF®, are widely used to prepare extemporaneous. An oral liquid preparation would be advantageous for patients, especially pediatric and adult patients, who are unable to swallow tablets or who must receive medications by nasogastric or. pension has a pH of ｾTNR to 4.4, whereas the pH of Although there is no set protocol to follow for the 1 % methylcellulose/syrup suspension is NXVｾ Other preparation of an extemporaneous liquid dosage form oral liquid vehicles include Ora-Sweet SF and Ora- from a tablet or capsule, it generally involves pulveri- Blend (Paddock Laboratories), SyrSpend SF (Gallipot zation of the tablets or. Physical and chemical properties of drugs and excipients should be considered when preparing extemporaneous formulations. These formulations, however, may lack studies to document stability. Preparation of Oral Liquids; Practices and Problems. If alternatives are not possible or the convenience and flexibility of a ready prepared product is preferred an extemporaneously compounded oral liquid might be considered. Add more vehicle to the paste until a liquid is formed and transfer the liquid into the container. 4. Use additional vehicle to rinse the remaining drug from the mortar and pour into the container. If there is need for an extemporaneous preparation of liquid, one must seek a commercially available alternative to avoid the DA. If none are available, the second option would be to search for a therapeutic equivalent. If there is no therapeutic equivalent with the same efficacy and safety, the third option would be the preparation of an extemporaneous solution, according to the pharmacopoeia. Helin-Tanninen, Minna Maarit. Extemporaneous preparation of paediatric oral formulations: Studies conducted in nifedipine powders, capsules and suspensions in a hospital pharmacy. Although there is no set protocol to follow for the preparation of an extemporaneous liquid dosage form from a tablet or capsule, it generally involves pulverization of the tablets or emptying the contents of the capsules into a mortar. A vehicle is selected, and a small quantity added to the powder and mixed to form a smooth paste. Additional vehicle is added in portions, with mixing, to the.