I'm trying to see if mixing wine/liquor with Xanax is doing harm to my BODY organs. I'm very responsible and have been in the rave scene, experimented with drugs etc been on tons of depression and anxiety meds it's not for me. Xanax is the only thing I prefer to help with my anxiety It is always not a good idea to mix xanax with a Alcohol. Alprazolam has a short half life meaning it doesent stay in your system its like 6-12 hours but if you take it everyday for 8 years then it has to be stored in your system but it is more deadly to quit xanax on the spot then alcohol just because it sounds like you dont drink everynight. No. Mixing Xanax with alcohol can cause reduce respiration, coma or death. Without knowing your dosing and other factors of your health, it could well be deadly. It depresses the nervous system. Without knowing your dosing and other factors of your health, it could well be deadly. As with many drugs, mixing Xanax® and alcohol is never a good idea, since the combination can produce results that range from mildly uncomfortable to fatal. It is important to understand that both Xanax® and alcohol are classified as central nervous system or CNS depressants. Taking Xanax with other drugs or alcohol can be a deadly mistake. According to the American Journal of Forensic Medicine and Pathology, fatalities from taking Xanax, or alprazolam, on its own are rare. Out of 178 postmortem studies reviewed by the journal, 87 deaths were caused by mixing drugs With these side effects in min, mixing Xanax and alcohol (including drinking on Xanax) is never a good idea. Whether it’s Xanax and beer, wine or any other alcoholic beverage, these two substances should never be combined in any way. I am having a tough time right now in my life with lots of different things. I am prescribed.5 mg 3X day and/or as needed. Thursday night I drank 12 12oz. malt liqour beers with 3.5 mgs of Xanax, I have felt sick and uneasy for three days now. Some people mix these two drugs without truly understanding the effects of mixing Xanax and alcohol. Taking Xanax with alcohol will intensify the effects of alcohol, which can cause increased drowsiness, dizziness, muscle weakness, confusion, coma, and death. No, Alprazolam (Xanax) is hydroxylated in the liver to α-hydroxyalprazolam, wherein the destructive effects begin. (which should be mild if anything) (which should be mild if anything) Alcohol is metabolized in the liver into acetyldehyde, which then is turned into acetic acid. What Makes Mixing Alcohol and Xanax So Dangerous? Xanax is a drug used to treat anxiety. You can avail of its generic form under alprazolam, which is its chemical name.