High prolactin levels may cause infertility. Another term for high prolactin levels is hyperprolactinemia. Women who are not pregnant and are not breastfeeding should have low levels of prolactin. If a non-pregnant woman has abnormally high levels of prolactin, it may cause her difficulty in becoming pregnant. Hyperprolactinaemia is the presence of abnormally high levels of prolactin in the blood. Normal levels are less than 500 mIU/L [20 ng/mL or µg/L] for women, and less than 450 mI U/L for men. Anyway, I also had gynocomastia from elevated prolactin levels. The surgery went fine, but I am noticing nipple puffiness again even though my E2 level is at a comfortable 27. The surgery went fine, but I am noticing nipple puffiness again even though my E2 level is at a comfortable 27. Summary. Blood prolactin increased is found among people who take Wellbutrin, especially for people who are female, 40-49 old also take medication Risperdal, and have Bipolar disorder. If you are producing milk, or your breasts are growing in size (like pregnant women large) then it could be causing an increase in prolactin. You really should speak with the doctor who prescribed your wellbutrin and have them monitor your prolactin levels if this is a concern. I am starting to really think that I will not be able to lose the weight until the prolactin returns to normal.when I was breastfeeding my kids I was not able to lose any of the pregnancy weight because my prolactin was high.@nybryx I am currently on Wellbutrin and I have noticed a little more focus being on it. Other drugs that can cause mild elevations of prolactin levels include estrogens and verapamil, a drug used to treat high blood pressure. An underactive thyroid or inadequate thyroid hormone replacement can also raise prolactin levels, as can kidney disease, pregnancy, stress, and chest trauma. Can Klonopin or Wellbutrin (bupropion) cause high prolactin levels? 1 doctor responded Psych says to increase my 150 MG Wellbutrin dose to receive full benefits. Can wellbutrin (bupropion) increase prolactin levels? How high is my risk of impotency with my med cocktail of zoloft, klonopin, lamictal, neurontin, wellbutrin, propranolol, requip and latuda (lurasidone)? Now the percentage of men may be relatively small, but keep in mind that a) the study was small and b) the threshold was 16.5 ng/ml. This is fairly high prolactin in my opinion.