Metformin is an oral diabetes medicine that helps control blood sugar levels. Metformin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Metformin And Headaches | Diabetic Connect. Hi all I dont know if this is a common side effect but I have had this annoying headache for the last 3 days. Commonly reported side effects of metformin include: lactic acidosis, diarrhea, nausea, nausea and vomiting, vomiting, and flatulence. Other side effects include: asthenia, and decreased vitamin b12 serum concentrate. Glyburide/metformin oral tablet is available only as a generic drug. It’s not available in a brand-name version. Glyburide/metformin only comes as a tablet you take by mouth. Headaches is found among people who take Metformin hydrochloride, especially for people who are female, 60+ old , have been taking the drug for 1 month, also take medication Aspirin, and have High blood pressure. Metformin hydrochloride is a type of antidiabetic medicine called a biguanide. It works in a number of ways to lower blood sugar levels in people with type 2 diabetes. Firstly, it increases the sensitivity of muscle cells to insulin. This enables these cells to remove sugar from the blood more effectively. Secondly, it reduces the amount of sugar produced by cells in the liver. Finally, it. How the study uses the data? The study is based on metformin hydrochloride (the active ingredients of Metformin) and Metformin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Metformin may also cause headaches, make your skin flush, cause changes to your fingernails, and cause muscle pain. Let your doctor know immediately if you start having chest pain or develop a rash while taking metformin. View detailed reports from patients taking Metformin Hydrochloride; Sitagliptin Phosphate who experienced headache. Reports are from official medical reports as well as online extractions from user reviews and forum discussions. Metformin can cause mild and serious side effects, which are the same in men and women. Here’s what you need to know about these side effects and when you should call your doctor.