For those of you who have had success with buspirone or Buspar, what time of day have you found most conducive to avoiding more of the. Hi ghm52-Everyone had good answers. I am on buspar, they are right, try to take it 2-3 times a day at the same time and either with or without food each time. You should not combine your morning and evening dose of Buspar (buspirone). Buspar is indicated to be dosed two to three times a day and taking the entire dose at once in the morning will likely result in effects of the drug not lasting all day. BuSpar should be taken at the same times each day to maintain an even level in your blood. BuSpar 15 mg and 30 mg tablets are specially designed to be able to split easily into half or in thirds. However, many people find that a pill splitter is necessary to accurately split these tablets into halves or thirds, since the tablets often split in the wrong places. How to use Buspar Tablet. Take this medication by mouth, usually 2 or 3 times a day or as directed by your doctor. You may take this medication with or without food, but it is important to choose. I am on Lexapro 15 mg a day, buspar 30 mg a day, and clonazopam 1 mg a day. Eventhough I take these meds I still don't feel 100 percent. I took Lexapro 10mg by itself for 8 years and no problems. A Eventhough I take these meds I still don't feel 100 percent. Some BuSpar tablets are scored so you can break the tablet into 2 or 3 pieces in order to take a smaller amount of the medicine at each dose. Do not use a tablet if it has not been broken correctly and the piece is too big or too small. Follow your doctor's instructions about how much of the tablet to take. When you take Buspar ( buspirone ) twice a day, you should space it out to every 12 hours if possible. However, you do not need to be to worried if it is not exact. Take it sometime in the morning and before bedtime. Just don't stress out over it:) Hi, I am on Remeron since May- right now my dose is 22.5 mgm each night. Buspar was added almost 4 weeks ago as my problem is severe anxiety. I started on Buspar 7.5 mgm 2 x day for a week, then was supposed to double it to 15 mgm 2 x day but it made me way to spacey so I went to 10 mgm 2 x day for a week. That is why it is best to take the 10mg three times per day. If this is cumbersome, and you won't be able to do that, talk to your doctor about splitting the dose into 15mg twice daily. This would still be better than taking it all together, but may be a bit easier to remember.