Prednisone and sun interaction is very common and it is not at all beneficial.The fact is that prednisone is a highly used drug because it is the most effective drug against inflammation and suppression of the nervous system. In order to define the time taken for any medicine to leave your body, it is essential to clear the concept of half-life. Half-life is the time required by 50% of the drug to leave your body. Have been on long-term prednisone therapy for 8 yrs. Developed Cushing syndrome, have taped off 65mg to 26mg, since this may as prescribed, without much trouble. I know it's a pain to go and be seen when you have symptoms when you can buy otc yeast treatments but you are immunosuppressed with the long term prednisone so it's well worth proper testing to make sure you aren't having issues with a strain of yeast that needs more aggressive treatments too. Upset. Prednisone does cause depression, as well stays in your system for a long time, but since you were on it a short time it could maybe stay in your body for about 2 to 3 weeks. So it will take roughly a week before it is mostly out of your system and you had a whopper of a dose. As an example, 5mg of pred is a replacement dose for thos. I have been on 20 mg. of prednisone everyday for the last few years. I have been on prednisone a smaller dose everyday for the ast 20 YEARS. My new Dr, just started a 5 mg decress daily I can not even tell you how bad the pain is I feel so sick. How scary. So sorry you are going through this. I was just given Prednisone for the second time in three months for breathing problems despite the fact that I told the doctor it didn’t help me at all the first time. The drug must be taken according to directions, since misuse, long-term use, or high doses can lead to undesirable side effects. Similarly, discontinuation of the drug in the proper way can help prevent symptoms of prednisone withdrawal. I'm 19, very healthy eater, and work out regularly. I took prednisone for 10 days on a taper, (60mg for 3 days, 40mg for 3 days, 20 mg for 3 days, 10 mg for one day).