I take topamax and five other meds for epilepsy, I have a VNS, so I have trouble sleeping as well, so my neurologist gives me klonopin at night, 2 mg, because it helps me sleep, it keeps seizures away, and it also help the nerve pain if I do have a seizure. Last year I was prescribed Topamax for mood disorders, and soon discovered its weight loss side effect. As it was so long ago I cannot quite remember how it was for me, but I think the main side effects I experienced were: Does Topiramate Cause Weight Loss: There is definitely proof that topiramate helps with weight loss, however be sure to check with your doctor before using. Topiramate (or Topamax) is generally an anticonvulsant medicine that widely used to treat epileptic seizures, migraine headache, anxiety, bipolar disorders, borderline personality disorder and nerve pain. Hi friends, My physician has given me a prescription for Topamax for weight loss support. This program will be supervised and I will see the Dr weekly. As an increasing number of people is overweight or obese pharmaceutical companies formulate drugs that are meant to kick-start the weight loss process. I started reading this thread because my doctor suggested I try Topamax for weight loss. So glad I did because I can't risk losing more hair (it is already very thin), so will not try the drug. And a JAMA meta-analysis and review of several drugs that could cause weight loss found that Topamax led obese patients to lose at least 5 percent of their body weight after taking it for a year. I’ve been on topamax twice before and luckily haven’t had any noticeable increase in hair loss. Unfortunately it didn’t have much effect on my migraines and I had problems with other side effects such as weight loss and fatigue. Weight loss was one of the most common side effects of Topamax, occurring in between 11 and 26 percent of patients taking the drug. According to Ortho-McNeil’s Topamax website, some patients lose weight while taking Topamax, and the amount of weight loss varies according to the dosage taken.