Metformin has a long-standing evidence base for efficacy and safety, is inexpensive, and is regarded by most as the primary first-line treatment for type 2 diabetes. This herb is better than metformin for diabetes. Last week, I told about the wonderful case of Rich. He’s a patient of mine with type-2 diabetes. Extended-release metformin is as effective as immediate-release metformin in patients newly started on metformin and those switched from the immediate-release formulation, with similar weight-neutral effects. Tolerability is generally comparable, although patients switched from the immediate-release formulation--even those switched due to GI intolerance--are often better able to tolerate the. There must be a difference. My diabetic friend gets very sick on Metformin, but never got sick on Glucophage. Doctor says insurance won't pay for Glucophage, of course, but hospitals won't use metformin because of the side effects. I have just been advised that glucophage is better than metformin,By a doctor whos mum is a daibetic, he says it works better for her. I have to pay more money for glugophage, and would rather spend the money if its better, I changed to generic metformin and havent so far noticed much difference. Glucophage (metformin) is used in patients with type 2 (non-insulin-dependent) diabetes. Includes Glucophage side effects, interactions and indications. Lowers blood sugar. Glucophage (metformin) is the first choice medicine to control your blood sugar and lower the risk of death from diabetes, although a few people may not tolerate the stomach side effects. Insulin Usually Better Than Oral Drugs For Type 2 Diabetes. According to a study published in , the combination of insulin and metformin may not benefit individuals with type 2 diabetes. Glumetza is specially designed to release the medication in the stomach, not in the intestines (as with other metformin products). This may decrease the intestinal-related side effects (such as diarrhea and gas).