My husband drinks at least one glass of wine/beer a day with more on weekends. I'm confused as to what excesive means or if he is suppose to avoid alcohol totally. Any information would be appreciated. The information reflected here is dependent upon the correct functioning of our algorithm. From time-to-time, our system might experience bugs or glitches that affect the accuracy or correct application of mathematical algorithms. It is generally acceptable to drink a glass of wine while taking metformin; however, it's best to be careful because of the risk of lactic acidosis. Additionally, there is a risk of hypoglycemia when a diabetes patient drinks alcohol, whether or not the patient takes metformin. Red Wine And Diabetes ★ Diabetes Drug Glipizide ★★ Red Wine And Diabetes ::The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days. Talk to your doctor before using ethanol together with glipiZIDE. Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. What should I discuss with my healthcare provider before taking glipizide (GlipiZIDE XL, Glucotrol, Glucotrol XL)? You should not use this medicine if you are allergic to glipizide, or if you have diabetic ketoacidosis (call your doctor for treatment). Glipizide works by helping your body to produce more insulin.I guess it's kind of like wine or grain alcohol, where it causes the body to over produce insulin (I would never suggest you start abusing alcohol to alleviate diabetes 2, but 1 serving per day could help)..