The aging of the population in the US and other countries means that a large number of people will likely take NSAIDs for the relief of pain and low-dose aspirin (LD-ASA) for cardioprotection. However, the cardioprotective value of LD-ASA can be Acenocoumarol is predicted to increase the risk of bleeding events when given with clopidogrel. Manufacturer advises use with caution or avoid. By Antony Q. Pham, Pharm.D. and Reena M. Tejura, Pharm.D. Faculty Peer Reviewed. Recent publications have described a potential drug interaction between clopidogrel (Plavix®) and proton pump inhibitors (PPIs). 3 FULL PRESCRIBING INFORMATION 1 INDICATIONS AND USAGE YOSPRALA, a combination of aspirin and omeprazole, is indicated for patients who require Proton Pump Inhibitors (PPIs) including Omeprazole, Rabeprazole, and Lansoprazole may reduce the efficacy of clopidogrel (Plavix) Advice for healthcare professionals. Concomitant use of clopidogrel and omeprazole or esomeprazole is to be discouraged unless considered essential. Uses. Omeprazole is used to treat certain stomach and esophagus problems (such as acid reflux, ulcers). It works by decreasing the amount of acid your stomach makes. Omeprazole reference guide for safe and effective use from the American Society of Health-System Pharmacists (AHFS DI). 20 mg PO once daily for 4 to 8 weeks. If a patient does not respond to 8 weeks of treatment, an additional 4 weeks of treatment may be given. If there is recurrence of erosive esophagitis, additional 4 to 8 week courses of omeprazole may be considered. Amlodipine Besilate 10 mg, 2. Lisinopril 20 mg,3. Atenolol 50 mg, and Omeprazole 20 mg for stomach) On 9/28, the Cardiologist resumes her with Warfarin (1 mg/day to start with) despite our request to leave the trial & switch to Aspirin.